HDH FISH Probe
The HDH FISH probe is designed to hybridize to the HDH gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HTT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HTT-20-RE | 20 (40 μL) | 200 μL |  |
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| HTT-20-GO | 20 (40 μL) | 200 μL |  |
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| HTT-20-GR | 20 (40 μL) | 200 μL |  |
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| HTT-20-AQ | 20 (40 μL) | 200 μL |  |
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| HTT-20-DIG | 20 (40 μL) | 200 μL |  |
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| HTT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: HTT
Gene Name: Huntingtin
Chromosome: CHR4: 3076407-3245687
Locus: 4p16.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HDH FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HTT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping