HB-1 FISH Probe
The HB-1 FISH probe is designed to hybridize to the HB-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PEG10-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PEG10-20-RE | 20 (40 μL) | 200 μL |  |
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| PEG10-20-GO | 20 (40 μL) | 200 μL |  |
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| PEG10-20-GR | 20 (40 μL) | 200 μL |  |
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| PEG10-20-AQ | 20 (40 μL) | 200 μL |  |
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| PEG10-20-DIG | 20 (40 μL) | 200 μL |  |
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| PEG10-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
Gene Details
Gene Symbol: PEG10
Gene Name: Paternally Expressed 10
Chromosome: CHR7: 94285636-94299006
Locus: 7q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HB-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PEG10-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping