GTF2H2 Break Apart FISH Probe
Empire Genomics’ GTF2H2 Break Apart FISH Probe is designed to flank the GTF2H2 gene and is typically used for detecting GTF2H2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GTF2H2BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-GORE | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-REGO | 20 (40 μL) | 200 μL |
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| GTF2H2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: GTF2H2
Gene Name: General Transcription Factor IIH Subunit 2
Chromosome: CHR5: 70330950-70363497
Locus: 5q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GTF2H2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GTF2H2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping