GSAP FISH Probe
The GSAP FISH probe is designed to hybridize to the GSAP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GSAP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| GSAP-20-RE | 20 (40 μL) | 200 μL |  |
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| GSAP-20-GO | 20 (40 μL) | 200 μL |  |
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| GSAP-20-GR | 20 (40 μL) | 200 μL |  |
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| GSAP-20-AQ | 20 (40 μL) | 200 μL |  |
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| GSAP-20-DIG | 20 (40 μL) | 200 μL |  |
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| GSAP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Gene Details
Gene Symbol: GSAP
Gene Name: Gamma-secretase Activating Protein
Chromosome: CHR7: 77416428-77310750
Locus: 7q11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GSAP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GSAP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping