GPR149 Break Apart FISH Probe
Empire Genomics’ GPR149 Break Apart FISH Probe is designed to flank the GPR149 gene and is typically used for detecting GPR149 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPR149BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPR149BA-20-AQOR | 20 (40 μL) | 200 μL |
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| GPR149BA-20-GOGR | 20 (40 μL) | 200 μL |
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| GPR149BA-20-GORE | 20 (40 μL) | 200 μL |
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| GPR149BA-20-GRGO | 20 (40 μL) | 200 μL |
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| GPR149BA-20-GRRE | 20 (40 μL) | 200 μL |
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| GPR149BA-20-ORGR | 20 (40 μL) | 200 μL |
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| GPR149BA-20-REGO | 20 (40 μL) | 200 μL |
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| GPR149BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Gene Details
Gene Symbol: GPR149
Gene Name: G Protein-coupled Receptor 149
Chromosome: CHR3: 154055460-154147504
Locus: 3q25.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GPR149 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GPR149-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping