GH-LCR FISH Probe
The GH-LCR FISH probe is designed to hybridize to the GH-LCR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GH-LCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-RE | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-GO | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-GR | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| GH-LCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This element represents a locus control region (LCR) that can confer copy number-dependent, position-independent expression on members of the human growth hormone gene cluster in transgenic assays. It regulates expression of the GH1 (growth hormone 1), CSHL1 (chorionic somatomammotropin hormone-like 1), CSH1 (chorionic somatomammotropin hormone 1 (placental lactogen)), GH2 (growth hormone 2) and CSH2 (chorionic somatomammotropin hormone 2) genes in this cluster. This LCR spans approximately 40 kb upstream of the GH1 gene and is characterized by five major DNase I hypersensitive sites (HSI-HSV). It overlaps the CD79B (CD79b molecule, immunoglobulin-associated beta) gene, and also the 3' end of the SCN4A (sodium channel, voltage gated, type IV alpha subunit) gene. This LCR includes several transcription factor binding sites as well as sub-regions with enhancer, enhancer-blocking and boundary element activity. Polymorphisms in this LCR may be associated with isolated growth hormone deficiency (IGHD), affecting serum IGF-I levels and height. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: GH-LCR
Gene Name: Growth Hormone Locus Control Region
Locus: 17q
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GH-LCR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GH-LCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping