GDNF Break Apart FISH Probe
Empire Genomics’ GDNF Break Apart FISH Probe is designed to flank the GDNF gene and is typically used for detecting GDNF rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GDNFBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| GDNFBA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: GDNF
Gene Name: Glial Cell Derived Neurotrophic Factor
Chromosome: CHR5: 37812778-37839782
Locus: 5p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: GDNF FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GDNF-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping