GCPII FISH Probe
The GCPII FISH probe is designed to hybridize to the GCPII gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FOLH1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-RE | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-GO | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-GR | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-AQ | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-DIG | 20 (40 μL) | 200 μL |  |
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| FOLH1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Gene Details
Gene Symbol: FOLH1
Gene Name: Folate Hydrolase 1
Chromosome: CHR11: 49168186-49230222
Locus: 11p11.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GCPII FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FOLH1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping