GCK FISH Probe
The GCK FISH probe is designed to hybridize to the GCK gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GCK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| GCK-20-RE | 20 (40 μL) | 200 μL |  |
|
| GCK-20-GO | 20 (40 μL) | 200 μL |  |
|
| GCK-20-GR | 20 (40 μL) | 200 μL |  |
|
| GCK-20-AQ | 20 (40 μL) | 200 μL |  |
|
| GCK-20-DIG | 20 (40 μL) | 200 μL |  |
|
| GCK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: GCK
Gene Name: Glucokinase
Chromosome: CHR7: 44183869-44229022
Locus: 7p13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: GCK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GCK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping