GCCR FISH Probe
The GCCR FISH probe is designed to hybridize to the GCCR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NR3C1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-RE | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-GO | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-GR | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-AQ | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-DIG | 20 (40 μL) | 200 μL |  |
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| NR3C1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: NR3C1
Gene Name: Nuclear Receptor Subfamily 3 Group C Member 1
Chromosome: CHR5: 142657495-142815077
Locus: 5q31.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GCCR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NR3C1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping