FURIN FISH Probe
The FURIN FISH probe is designed to hybridize to the FURIN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FURIN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FURIN-20-RE | 20 (40 μL) | 200 μL |  |
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| FURIN-20-GO | 20 (40 μL) | 200 μL |  |
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| FURIN-20-GR | 20 (40 μL) | 200 μL |  |
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| FURIN-20-AQ | 20 (40 μL) | 200 μL |  |
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| FURIN-20-DIG | 20 (40 μL) | 200 μL |  |
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| FURIN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Details
Gene Symbol: FURIN
Gene Name: Furin, Paired Basic Amino Acid Cleaving Enzyme
Chromosome: CHR15: 91411884-91426687
Locus: 15q26.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FURIN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FURIN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping