FSHD FISH Probe
The FSHD FISH probe is designed to hybridize to the FSHD gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FSHMD1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-RE | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-GO | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-GR | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| FSHMD1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Facioscapulohumeral muscular dystrophy (FSHD) is a common hereditary disease of muscle. Patients with FSHD have a chromosomal rearrangement within the subtelomeric region of chromosome 4 (4q35). This region is composed mainly of a polymorphic repeat structure consisting of 3.3 kb repeat units, designated D4Z4. The number of repeat units varies from 10 to more than 100 in the population, however, in FSHD patients only 1-10 repeat units is observed because of a deletion of an integral number of these units. FSHD is caused by an epigenetic mechanism involving the contraction of a subtelomeric macrosatellite repeat, which results in marked hypomethylation of the contracted D4Z4 allele. It is likely not the structure, but the deregulation of transcription of one or more genes as a result of repeat-contraction-mediated chromatin alterations, that causes FSHD. [provided by RefSeq, Sep 2011]
Gene Details
Gene Symbol: FSHMD1A
Gene Name: Facioscapulohumeral Muscular Dystrophy 1A
Locus: 4q35
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FSHD FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FSHMD1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping