FMO3 FISH Probe
The FMO3 FISH probe is designed to hybridize to the FMO3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FMO3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FMO3-20-RE | 20 (40 μL) | 200 μL |  |
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| FMO3-20-GO | 20 (40 μL) | 200 μL |  |
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| FMO3-20-GR | 20 (40 μL) | 200 μL |  |
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| FMO3-20-AQ | 20 (40 μL) | 200 μL |  |
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| FMO3-20-DIG | 20 (40 μL) | 200 μL |  |
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| FMO3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: FMO3
Gene Name: Flavin Containing Monooxygenase 3
Chromosome: CHR1: 171060017-171086959
Locus: 1q24.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FMO3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FMO3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping