FKBP4 Break Apart FISH Probe
Empire Genomics’ FKBP4 Break Apart FISH Probe is designed to flank the FKBP4 gene and is typically used for detecting FKBP4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FKBP4BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-GORE | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-GROR | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-REGO | 20 (40 μL) | 200 μL |
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| FKBP4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Gene Details
Gene Symbol: FKBP4
Gene Name: FK506 Binding Protein 4
Chromosome: CHR12: 2904107-2914587
Locus: 12p13.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Delineation of human prostate cancer evolution identifies chromothripsis as a polyclonal event and FKBP4 as a potential driver of castration resistance
Product Details
Product: FKBP4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FKBP4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping