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FGFR1 Break Apart FISH Probe

Empire Genomics’ FGFR1 Break Apart FISH Probe is designed to flank the FGFR1 gene and is typically used for detecting FGFR1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
FGFR1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
FGFR1BA-20-AQOR 20 (40 μL) 200 μL
FGFR1BA-20-GOGR 20 (40 μL) 200 μL
FGFR1BA-20-GORE 20 (40 μL) 200 μL
FGFR1BA-20-GRGO 20 (40 μL) 200 μL
FGFR1BA-20-GRRE 20 (40 μL) 200 μL
FGFR1BA-20-ORGR 20 (40 μL) 200 μL
FGFR1BA-20-REGO 20 (40 μL) 200 μL
FGFR1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: FGFR1

Gene Name: Fibroblast Growth Factor Receptor 1

Chromosome: CHR8: 38268655-38326352

Locus: 8p11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

FGFR1 and HER1 or HER2 co-amplification in breast cancer indicate poor prognosis

HER1, HER2, and FGFR1 are important in the progression of breast cancer. The copy number variation of HER1/2 and FGFR1 in invasive ductal breast cancer (IDC) were under study. Various FISH tests were performed including one with our FGFR1 probe. It was concluded that those with co-amplification of FGFR1 and HER1/2 faced a less favorable prognosis than those with single or no amplification of these genes.
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LobSig is a multigene predictor of outcome in invasive lobular carcinoma

Invasive lobular carcinoma (ILC) is a type of breast cancer defined by functional loss of E-cadherin, which results in cellular adhesion defects. This study sought to further characterize ILC’s genetic profile via analysis of 196 tumors. Using in silico integrative analyses, a 194-gene set – named ‘LobSig’ by the team – was identified, made up of genes frequently mutated in the tumor samples. LobSig was tested against the Nottingham Prognostic Index, PAM50 risk-of-recurrence (Prosigna), OncotypeDx, and Genomic Grade Index (MapQuantDx) for a 10-year follow-up period, and outperformed them all. As part of genetic profiling, Empire Genomics’ FGFR1 And CCND1 FISH probes were used to detect amplification of the genes.
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Product Details

Product: FGFR1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: FGFR1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping