FEN1 Break Apart FISH Probe
Empire Genomics’ FEN1 Break Apart FISH Probe is designed to flank the FEN1 gene and is typically used for detecting FEN1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FEN1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FEN1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| FEN1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| FEN1BA-20-GORE | 20 (40 μL) | 200 μL |
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| FEN1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| FEN1BA-20-GROR | 20 (40 μL) | 200 μL |
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| FEN1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| FEN1BA-20-REGO | 20 (40 μL) | 200 μL |
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| FEN1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: FEN1
Gene Name: Flap Structure-specific Endonuclease 1
Chromosome: CHR11: 61560108-61564714
Locus: 11q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FEN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FEN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping