FBXW7 FISH Probe
The FBXW7 FISH probe is designed to hybridize to the FBXW7 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXW7-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-RE | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-GO | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-GR | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-AQ | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-DIG | 20 (40 μL) | 200 μL |  |
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| FBXW7-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Details
Gene Symbol: FBXW7
Gene Name: F-box And WD Repeat Domain Containing 7
Chromosome: CHR4: 153242409-153456172
Locus: 4q31.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FBXW7 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FBXW7-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping