FBXO11 FISH Probe
The FBXO11 FISH probe is designed to hybridize to the FBXO11 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXO11-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-RE | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-GO | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-GR | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-AQ | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-DIG | 20 (40 μL) | 200 μL |  |
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| FBXO11-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Gene Details
Gene Symbol: FBXO11
Gene Name: F-box Protein 11
Chromosome: CHR2: 48034058-48132932
Locus: 2p16.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FBXO11 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FBXO11-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping