F13B FISH Probe
The F13B FISH probe is designed to hybridize to the F13B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| F13B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| F13B-20-RE | 20 (40 μL) | 200 μL |  |
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| F13B-20-GO | 20 (40 μL) | 200 μL |  |
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| F13B-20-GR | 20 (40 μL) | 200 μL |  |
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| F13B-20-AQ | 20 (40 μL) | 200 μL |  |
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| F13B-20-DIG | 20 (40 μL) | 200 μL |  |
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| F13B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: F13B
Gene Name: Coagulation Factor XIII B Chain
Chromosome: CHR1: 197008320-197036397
Locus: 1q31.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: F13B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: F13B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping