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F13B FISH Probe

The F13B FISH probe is designed to hybridize to the F13B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
F13B-20-OR  (Standard Design) 20 (40 μL) 200 μL
F13B-20-RE 20 (40 μL) 200 μL
F13B-20-GO 20 (40 μL) 200 μL
F13B-20-GR 20 (40 μL) 200 μL
F13B-20-AQ 20 (40 μL) 200 μL
F13B-20-DIG 20 (40 μL) 200 μL
F13B-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: F13B

Gene Name: Coagulation Factor XIII B Chain

Chromosome: CHR1: 197008320-197036397

Locus: 1q31.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: F13B FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: F13B-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping