F12 FISH Probe
The F12 FISH probe is designed to hybridize to the F12 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| F12-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| F12-20-RE | 20 (40 μL) | 200 μL |  |
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| F12-20-GO | 20 (40 μL) | 200 μL |  |
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| F12-20-GR | 20 (40 μL) | 200 μL |  |
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| F12-20-AQ | 20 (40 μL) | 200 μL |  |
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| F12-20-DIG | 20 (40 μL) | 200 μL |  |
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| F12-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: F12
Gene Name: Coagulation Factor XII
Chromosome: CHR5: 176829138-176836577
Locus: 5q35.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: F12 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: F12-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping