EWSR1 Break Apart FISH Probe
Empire Genomics’ EWSR1 Break Apart FISH Probe is designed to flank the EWSR1 gene and is typically used for detecting EWSR1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EWSR1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-GORE | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-GROR | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-REGO | 20 (40 μL) | 200 μL |
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| EWSR1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Gene Details
Gene Symbol: EWSR1
Gene Name: EWS RNA Binding Protein 1
Chromosome: CHR22: 29663997-29696515
Locus: 22q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: EWSR1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: EWSR1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping