ESRRG FISH Probe
The ESRRG FISH probe is designed to hybridize to the ESRRG gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ESRRG-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-RE | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-GO | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-GR | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-AQ | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-DIG | 20 (40 μL) | 200 μL |  |
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| ESRRG-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: ESRRG
Gene Name: Estrogen Related Receptor Gamma
Chromosome: CHR1: 216676587-217311097
Locus: 1q41
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ESRRG FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ESRRG-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping