ESPL1 Break Apart FISH Probe
Empire Genomics’ ESPL1 Break Apart FISH Probe is designed to flank the ESPL1 gene and is typically used for detecting ESPL1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ESPL1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-GORE | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-GROR | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-REGO | 20 (40 μL) | 200 μL |
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| ESPL1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Gene Details
Gene Symbol: ESPL1
Gene Name: Extra Spindle Pole Bodies Like 1, Separase
Chromosome: CHR12: 53662082-53687427
Locus: 12q13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ESPL1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ESPL1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping