ERVPRODH FISH Probe
The ERVPRODH FISH probe is designed to hybridize to the ERVPRODH gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERVPRODH-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-RE | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-GO | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-GR | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-AQ | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-DIG | 20 (40 μL) | 200 μL |  |
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| ERVPRODH-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This region includes a endogenous retrovirus long-terminal repeat (LTR)-derived sequence that binds SRY (sex determining region Y)-box 2 (SOX2) and functions as an enhancer of the proline dehydrogenase (oxidase) 1 (PRODH) gene. This sequence acts synergistically with a CG-rich region downstream of the transcription start site to promote expression of PRODH. Cytosine methylation of the LTR element but not the CG-region can block enhancer activity. The orthologous sequence in chimpanzee does not function as an enhancer, suggesting that regulation by this region is human-specific. [provided by RefSeq, Oct 2015]
Gene Details
Gene Symbol: ERVPRODH
Gene Name: Human-specific Endogenous Retroviral Insert (PRODH)
Locus: 22q11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ERVPRODH FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ERVPRODH-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping