ERG FISH Probe
The ERG FISH probe is designed to hybridize to the ERG gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERG-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ERG-20-RE | 20 (40 μL) | 200 μL |  |
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| ERG-20-GO | 20 (40 μL) | 200 μL |  |
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| ERG-20-GR | 20 (40 μL) | 200 μL |  |
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| ERG-20-AQ | 20 (40 μL) | 200 μL |  |
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| ERG-20-DIG | 20 (40 μL) | 200 μL |  |
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| ERG-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Details
Gene Symbol: ERG
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182-40033618
Locus: 21q22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ERG FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ERG-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping