ERBB2 FISH Probe
The ERBB2 FISH probe is designed to hybridize to the ERBB2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERBB2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-RE | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-GO | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-GR | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-AQ | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-DIG | 20 (40 μL) | 200 μL |  |
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| ERBB2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ERBB2
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392-37884915
Locus: 17q12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ERBB2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ERBB2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping