ELM-1 FISH Probe
The ELM-1 FISH probe is designed to hybridize to the ELM-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| WISP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| WISP1-20-RE | 20 (40 μL) | 200 μL |  |
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| WISP1-20-GO | 20 (40 μL) | 200 μL |  |
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| WISP1-20-GR | 20 (40 μL) | 200 μL |  |
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| WISP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| WISP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| WISP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
Gene Details
Gene Symbol: WISP1
Gene Name: WNT1 Inducible Signaling Pathway Protein 1
Chromosome: CHR8: 134203281-134243932
Locus: 8q24.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ELM-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: WISP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping