ELANE Break Apart FISH Probe
Empire Genomics’ ELANE Break Apart FISH Probe is designed to flank the ELANE gene and is typically used for detecting ELANE rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELANEBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELANEBA-20-AQOR | 20 (40 μL) | 200 μL |
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| ELANEBA-20-GOGR | 20 (40 μL) | 200 μL |
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| ELANEBA-20-GORE | 20 (40 μL) | 200 μL |
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| ELANEBA-20-GRGO | 20 (40 μL) | 200 μL |
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| ELANEBA-20-GROR | 20 (40 μL) | 200 μL |
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| ELANEBA-20-GRRE | 20 (40 μL) | 200 μL |
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| ELANEBA-20-REGO | 20 (40 μL) | 200 μL |
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| ELANEBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: ELANE
Gene Name: Elastase, Neutrophil Expressed
Chromosome: CHR19: 852290-856246
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ELANE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ELANE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping