E2F4 Break Apart FISH Probe
Empire Genomics’ E2F4 Break Apart FISH Probe is designed to flank the E2F4 gene and is typically used for detecting E2F4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| E2F4BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| E2F4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| E2F4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| E2F4BA-20-GORE | 20 (40 μL) | 200 μL |
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| E2F4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| E2F4BA-20-GROR | 20 (40 μL) | 200 μL |
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| E2F4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| E2F4BA-20-REGO | 20 (40 μL) | 200 μL |
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| E2F4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: E2F4
Gene Name: E2F Transcription Factor 4
Chromosome: CHR16: 67226067-67232821
Locus: 16q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: E2F4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: E2F4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping