DUSP3 Break Apart FISH Probe
Empire Genomics’ DUSP3 Break Apart FISH Probe is designed to flank the DUSP3 gene and is typically used for detecting DUSP3 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DUSP3BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-AQOR | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-GOGR | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-GORE | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-GRGO | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-GRRE | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-ORGR | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-REGO | 20 (40 μL) | 200 μL |
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| DUSP3BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: DUSP3
Gene Name: Dual Specificity Phosphatase 3
Chromosome: CHR17: 41843488-41856368
Locus: 17q21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DUSP3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DUSP3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping