DUOXA1 Break Apart FISH Probe
Empire Genomics’ DUOXA1 Break Apart FISH Probe is designed to flank the DUOXA1 gene and is typically used for detecting DUOXA1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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DUOXA1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-AQOR | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-GOGR | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-GORE | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-GRGO | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-GRRE | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-ORGR | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-REGO | 20 (40 μL) | 200 μL | ||
DUOXA1BA-20-REGR | 20 (40 μL) | 200 μL |
Gene Summary
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: DUOXA1
Gene Name: Dual Oxidase Maturation Factor 1
Chromosome: CHR15: 45409685-45422057
Locus: 15q21.1
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DUOXA1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DUOXA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping