SEARCH OUR PRODUCT CATALOG

As of September 21st, Empire is operating as an essential New York State business and has no production or shipping delays

DUOXA1 FISH Probe

The DUOXA1 FISH probe is designed to hybridize to the DUOXA1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
DUOXA1-20-OR  (Standard Design) 20 (40 μL) 200 μL
DUOXA1-20-RE 20 (40 μL) 200 μL
DUOXA1-20-GO 20 (40 μL) 200 μL
DUOXA1-20-GR 20 (40 μL) 200 μL
DUOXA1-20-AQ 20 (40 μL) 200 μL
DUOXA1-20-DIG 20 (40 μL) 200 μL
DUOXA1-20-BIO 20 (40 μL) 200 μL

Gene Summary

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Details

Gene Symbol: DUOXA1

Gene Name: Dual Oxidase Maturation Factor 1

Chromosome: CHR15: 45409685-45422057

Locus: 15q21.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: DUOXA1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: DUOXA1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping