DSPP FISH Probe
The DSPP FISH probe is designed to hybridize to the DSPP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DMP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DMP1-20-RE | 20 (40 μL) | 200 μL |  |
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| DMP1-20-GO | 20 (40 μL) | 200 μL |  |
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| DMP1-20-GR | 20 (40 μL) | 200 μL |  |
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| DMP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| DMP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| DMP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: DMP1
Gene Name: Dentin Matrix Acidic Phosphoprotein 1
Chromosome: CHR4: 88571453-88585512
Locus: 4q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DSPP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DMP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping