DPTEN FISH Probe
The DPTEN FISH probe is designed to hybridize to the DPTEN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTEN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PTEN-20-RE | 20 (40 μL) | 200 μL |  |
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| PTEN-20-GO | 20 (40 μL) | 200 μL |  |
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| PTEN-20-GR | 20 (40 μL) | 200 μL |  |
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| PTEN-20-AQ | 20 (40 μL) | 200 μL |  |
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| PTEN-20-DIG | 20 (40 μL) | 200 μL |  |
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| PTEN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Details
Gene Symbol: PTEN
Gene Name: Phosphatase And Tensin Homolog
Chromosome: CHR10: 89623194-89728532
Locus: 10q23.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DPTEN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTEN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping