DOCK3 FISH Probe
The DOCK3 FISH probe is designed to hybridize to the DOCK3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DOCK3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-RE | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-GO | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-GR | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-AQ | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-DIG | 20 (40 μL) | 200 μL |  |
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| DOCK3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Gene Details
Gene Symbol: DOCK3
Gene Name: Dedicator Of Cytokinesis 3
Chromosome: CHR3: 50712671-51421629
Locus: 3p21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DOCK3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DOCK3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping