DMTN FISH Probe
The DMTN FISH probe is designed to hybridize to the DMTN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DMTN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DMTN-20-RE | 20 (40 μL) | 200 μL |  |
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| DMTN-20-GO | 20 (40 μL) | 200 μL |  |
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| DMTN-20-GR | 20 (40 μL) | 200 μL |  |
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| DMTN-20-AQ | 20 (40 μL) | 200 μL |  |
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| DMTN-20-DIG | 20 (40 μL) | 200 μL |  |
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| DMTN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Gene Details
Gene Symbol: DMTN
Gene Name: Dematin Actin Binding Protein
Chromosome: CHR8: 22048954-22082526
Locus: 8p21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DMTN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DMTN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping