DMSR-1 FISH Probe
The DMSR-1 FISH probe is designed to hybridize to the DMSR-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MSR1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MSR1-20-RE | 20 (40 μL) | 200 μL |  |
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| MSR1-20-GO | 20 (40 μL) | 200 μL |  |
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| MSR1-20-GR | 20 (40 μL) | 200 μL |  |
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| MSR1-20-AQ | 20 (40 μL) | 200 μL |  |
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| MSR1-20-DIG | 20 (40 μL) | 200 μL |  |
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| MSR1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MSR1
Gene Name: Macrophage Scavenger Receptor 1
Chromosome: CHR8: 15965386-16050300
Locus: 8p22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DMSR-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MSR1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping