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DMRT1 FISH Probe

The DMRT1 FISH probe is designed to hybridize to the DMRT1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
DMRT1-20-OR  (Standard Design) 20 (40 μL) 200 μL
DMRT1-20-RE 20 (40 μL) 200 μL
DMRT1-20-GO 20 (40 μL) 200 μL
DMRT1-20-GR 20 (40 μL) 200 μL
DMRT1-20-AQ 20 (40 μL) 200 μL
DMRT1-20-DIG 20 (40 μL) 200 μL
DMRT1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: DMRT1

Gene Name: Doublesex And Mab-3 Related Transcription Factor 1

Chromosome: CHR9: 841689-969090

Locus: 9p24.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Loss of DMRT1 gene in a Mos 45,XY,-9[8]/46,XY,r(9)[29]/47,XY,+idic r(9)x2[1]/46,XY,idic r(9)[1]/46,XY[1] female presenting with short stature

A 46,XY sex reversal syndrome is characterized genetically by aberrations in chromosome 9pter due to involvement of the DMRT1 gene. A case study was under analysis to better understand the syndrome. FISH analysis was used with our DMRT1 gene probe. It was found that sex reversal can be due to haploinsufficiency of the DMRT1 gene in ring chromosome 9, although it is rare. This finding highlights the importance of the DMRT1 gene in sex determination.
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Product Details

Product: DMRT1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: DMRT1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping