DMPK Break Apart FISH Probe
Empire Genomics’ DMPK Break Apart FISH Probe is designed to flank the DMPK gene and is typically used for detecting DMPK rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMPKBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMPKBA-20-AQOR | 20 (40 μL) | 200 μL |
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| DMPKBA-20-GOGR | 20 (40 μL) | 200 μL |
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| DMPKBA-20-GORE | 20 (40 μL) | 200 μL |
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| DMPKBA-20-GRGO | 20 (40 μL) | 200 μL |
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| DMPKBA-20-GRRE | 20 (40 μL) | 200 μL |
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| DMPKBA-20-ORGR | 20 (40 μL) | 200 μL |
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| DMPKBA-20-REGO | 20 (40 μL) | 200 μL |
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| DMPKBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: DMPK
Gene Name: DM1 Protein Kinase
Chromosome: CHR19: 46272975-46285815
Locus: 19q13.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DMPK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DMPK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping