DM18 FISH Probe
The DM18 FISH probe is designed to hybridize to the DM18 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| XBP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| XBP1-20-RE | 20 (40 μL) | 200 μL |  |
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| XBP1-20-GO | 20 (40 μL) | 200 μL |  |
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| XBP1-20-GR | 20 (40 μL) | 200 μL |  |
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| XBP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| XBP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| XBP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: XBP1
Gene Name: X-box Binding Protein 1
Chromosome: CHR22: 29190547-29196560
Locus: 22q12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DM18 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: XBP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping