DIO3 FISH Probe
The DIO3 FISH probe is designed to hybridize to the DIO3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DIO3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DIO3-20-RE | 20 (40 μL) | 200 μL |  |
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| DIO3-20-GO | 20 (40 μL) | 200 μL |  |
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| DIO3-20-GR | 20 (40 μL) | 200 μL |  |
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| DIO3-20-AQ | 20 (40 μL) | 200 μL |  |
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| DIO3-20-DIG | 20 (40 μL) | 200 μL |  |
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| DIO3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]
Gene Details
Gene Symbol: DIO3
Gene Name: Iodothyronine Deiodinase 3
Chromosome: CHR14: 102027687-102029789
Locus: 14q32.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DIO3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DIO3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping