DGS FISH Probe
The DGS FISH probe is designed to hybridize to the DGS gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DGCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DGCR-20-RE | 20 (40 μL) | 200 μL |  |
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| DGCR-20-GO | 20 (40 μL) | 200 μL |  |
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| DGCR-20-GR | 20 (40 μL) | 200 μL |  |
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| DGCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| DGCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| DGCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
DiGeorge syndrome (DGS) comprises hypocalcemia arising from parathyroid hypoplasia, thymic hypoplasia, and outflow tract defects of the heart. Disturbance of cervical neural crest migration into the derivatives of the pharyngeal arches and pouches can account for the phenotype. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR). Several genes are lost including the putative transcription factor TUPLE1 which is expressed in the appropriate distribution. This deletion may present with a variety of phenotypes: Shprintzen, or velocardiofacial, syndrome (VCFS; MIM 192430); conotruncal anomaly face (or Takao syndrome); and isolated outflow tract defects of the heart including tetralogy of Fallot, truncus arteriosus, and interrupted aortic arch. A collective acronym CATCH22 has been proposed for these differing presentations. A small number of cases of DGS have defects in other chromosomes, notably 10p13 (see MIM 601362). In the mouse, a transgenic Hox A3 (Hox 1.5) knockout produces a phenotype similar to DGS as do the teratogens retinoic acid and alcohol.[supplied by OMIM, Aug 2009]
Gene Details
Gene Symbol: DGCR
Gene Name: DiGeorge Syndrome Chromosome Region
Locus: 22q11.21-q11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DGS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DGCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping