DFNB77 FISH Probe
The DFNB77 FISH probe is designed to hybridize to the DFNB77 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LOXHD1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-RE | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-GO | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-GR | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-AQ | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-DIG | 20 (40 μL) | 200 μL |  |
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| LOXHD1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins to the plasma membrane. Studies in mice show that this gene is expressed in the mechanosensory hair cells in the inner ear, and mutations in this gene lead to auditory defects, indicating that this gene is essential for normal hair cell function. Screening of human families segregating deafness identified a mutation in this gene which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL). Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
Gene Details
Gene Symbol: LOXHD1
Gene Name: Lipoxygenase Homology Domains 1
Chromosome: CHR18: 44057216-44236996
Locus: 18q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DFNB77 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LOXHD1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping