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DFNB76 FISH Probe

The DFNB76 FISH probe is designed to hybridize to the DFNB76 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SYNE4-20-OR  (Standard Design) 20 (40 μL) 200 μL
SYNE4-20-RE 20 (40 μL) 200 μL
SYNE4-20-GO 20 (40 μL) 200 μL
SYNE4-20-GR 20 (40 μL) 200 μL
SYNE4-20-AQ 20 (40 μL) 200 μL
SYNE4-20-DIG 20 (40 μL) 200 μL
SYNE4-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Gene Details

Gene Symbol: SYNE4

Gene Name: Spectrin Repeat Containing Nuclear Envelope Family Member 4

Chromosome: CHR19: 36008792-36003298

Locus: 19q13.12

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: DFNB76 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: SYNE4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping