DFF-45 FISH Probe
The DFF-45 FISH probe is designed to hybridize to the DFF-45 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DFFA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DFFA-20-RE | 20 (40 μL) | 200 μL |  |
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| DFFA-20-GO | 20 (40 μL) | 200 μL |  |
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| DFFA-20-GR | 20 (40 μL) | 200 μL |  |
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| DFFA-20-AQ | 20 (40 μL) | 200 μL |  |
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| DFFA-20-DIG | 20 (40 μL) | 200 μL |  |
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| DFFA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: DFFA
Gene Name: DNA Fragmentation Factor Subunit Alpha
Chromosome: CHR1: 10520602-10532613
Locus: 1p36.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DFF-45 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DFFA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping