DES-LCR Break Apart FISH Probe
Empire Genomics’ DES-LCR Break Apart FISH Probe is designed to flank the DES-LCR gene and is typically used for detecting DES-LCR rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DES-LCRBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-AQOR | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-GORE | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-ORGR | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-REGO | 20 (40 μL) | 200 μL |
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| DES-LCRBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This region represents a locus control region (LCR) that regulates expression of the DES (desmin) gene, whereby it can confer copy number-dependent and position of integration-independent muscle-specific developmental expression on this gene. It is also thought, though not yet demonstrated, that this LCR may control expression of the preferentially muscle-expressed SPEG (SPEG complex locus) gene that exists downstream of the DES gene. This LCR is characterized by the presence of five major DNase I hypersensitive sites (HSs), which bind factors that mediate developmental expression of the DES gene. This region also includes a promoter-proximal enhancer that can drive DES gene expression in skeletal but not cardiac muscle. This LCR and enhancer region can drive expression of other muscle-specific genes, and it is a potential regulatory element for use in muscle-specific gene therapy vectors. [provided by RefSeq, Dec 2015]
Gene Details
Gene Symbol: DES-LCR
Gene Name: Desmin Locus Control Region
Locus: 2q35
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DES-LCR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DES-LCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping