DES-LCR FISH Probe
The DES-LCR FISH probe is designed to hybridize to the DES-LCR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DES-LCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-RE | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-GO | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-GR | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| DES-LCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This region represents a locus control region (LCR) that regulates expression of the DES (desmin) gene, whereby it can confer copy number-dependent and position of integration-independent muscle-specific developmental expression on this gene. It is also thought, though not yet demonstrated, that this LCR may control expression of the preferentially muscle-expressed SPEG (SPEG complex locus) gene that exists downstream of the DES gene. This LCR is characterized by the presence of five major DNase I hypersensitive sites (HSs), which bind factors that mediate developmental expression of the DES gene. This region also includes a promoter-proximal enhancer that can drive DES gene expression in skeletal but not cardiac muscle. This LCR and enhancer region can drive expression of other muscle-specific genes, and it is a potential regulatory element for use in muscle-specific gene therapy vectors. [provided by RefSeq, Dec 2015]
Gene Details
Gene Symbol: DES-LCR
Gene Name: Desmin Locus Control Region
Locus: 2q35
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DES-LCR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DES-LCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping