DD3 FISH Probe
The DD3 FISH probe is designed to hybridize to the DD3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCA3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-RE | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-GO | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-GR | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-AQ | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-DIG | 20 (40 μL) | 200 μL |  |
|
| PCA3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Gene Details
Gene Symbol: PCA3
Gene Name: Prostate Cancer Associated 3 (non-protein Coding)
Chromosome: CHR9: 79379353-79402465
Locus: 9q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: DD3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCA3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping