DCTN1 FISH Probe
The DCTN1 FISH probe is designed to hybridize to the DCTN1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DCTN1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-RE | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-GO | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-GR | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-AQ | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-DIG | 20 (40 μL) | 200 μL |  |
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| DCTN1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: DCTN1
Gene Name: Dynactin Subunit 1
Chromosome: CHR2: 74588280-74619214
Locus: 2p13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DCTN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DCTN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping