DCSIGNR FISH Probe
The DCSIGNR FISH probe is designed to hybridize to the DCSIGNR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CLEC4M-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-RE | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-GO | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-GR | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-AQ | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-DIG | 20 (40 μL) | 200 μL |  |
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| CLEC4M-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene Details
Gene Symbol: CLEC4M
Gene Name: C-type Lectin Domain Family 4 Member M
Chromosome: CHR19: 7828034-7834491
Locus: 19p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DCSIGNR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CLEC4M-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping